Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches
نویسندگان
چکیده
منابع مشابه
Multimodal Imaging of Photoreceptor Structure in Choroideremia
PURPOSE Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions. METHODS Twelve males with clinically-diagnosed choroideremia and c...
متن کاملCharacterizing the Natural History of Visual Function in Choroideremia Using Microperimetry and Multimodal Retinal Imaging
Purpose Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (BCVA), microperimetry and multimodal imaging. Methods Fifty-six consecutive ...
متن کاملMultimodal Emotion Recognition Using Multimodal Deep Learning
To enhance the performance of affective models and reduce the cost of acquiring physiological signals for real-world applications, we adopt multimodal deep learning approach to construct affective models from multiple physiological signals. For unimodal enhancement task, we indicate that the best recognition accuracy of 82.11% on SEED dataset is achieved with shared representations generated by...
متن کاملHigh-resolution images of retinal structure in patients with choroideremia.
PURPOSE To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. METHODS Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-field electroretinography, and fundus autofluorescence (FAF). High-resolutio...
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Cognitive decline is a characteristic feature of normal human aging. Previous work has demonstrated marked interindividual variability in onset and rate of decline. Such variability has been linked to factors such as maintenance of functional and structural brain integrity, genetics, and lifestyle. Still, few, if any, studies have combined a longitudinal design with repeated multimodal imaging ...
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ژورنال
عنوان ژورنال: Eye
سال: 2020
ISSN: 0950-222X,1476-5454
DOI: 10.1038/s41433-020-0974-1